Hidroxipropilmetilcelulose (HPMC) Atacado

Hydroxypropyl Methylcellulose (HPMC) Uses

Hydroxypropyl Methylcellulose (HPMC) is mainly derived from refined cotton/wood pulp, which is alkalized to obtain cellulose, and then added with propylene oxide and methyl chloride for etherification to obtain cellulose ether.

HPMC Cellulose act as thickener, water retaining agent, dispersant, stabilizer, emulsifier, binder, excipient, film former in various industries. HPM cellulose is widely used in construction dry-mixed mortar, pharmaceutical, petrochemical, ceramics, paper, synthetic resin, leather, food and cosmetics and other industries.

KimaCell® Hydroxypropyl Methylcellulose (HPMC) has the advantages of wide application, small unit usage, good modification effect, and environmental friendliness. HPMC products can significantly improve and optimize product performance in the field of its addition, which is conducive to improving resource utilization efficiency and product added value. Environmentally friendly additives that are essential in various fields.

1. HPMC In Pharmaceutical

In the field of medicine, Hydroxypropyl Methylcellulose (HPMC) is an important pharmaceutical excipient, which can be used in drug sustained and controlled release preparations, vegetable capsules, tablet coatings, suspending agents, tablet binders, tablet disintegrants and other application scenarios.

2. Hydroxypropyl Methyl Cellulose In Food

Food grade Hydroxypropyl Methylcellulose (HPMC) is a recognized safe food additive. It can be used as a food thickener, stabilizer and moisturizer to thicken, retain water, and improve taste. It is widely used in developed countries, mainly for baked food, collagen Protein casings, whipped cream, fruit juices, sauces, meat and other protein products, fried foods, etc. China, the United States, the European Union, and many other countries allow HPMC to be used as a food additive.

The proportion of food-grade Hydroxypropyl Methylcellulose (HPMC) used in food production in China is relatively low. The domestic market is still in the stage of application and promotion, coupled with the high price of food-grade HPMC, HPMC is used in fewer fields in food production in my country. However, with the improvement of income, the scale of the food industry is expected to maintain steady growth in the long run. Moreover, with the improvement of people's awareness of healthy food, the penetration rate of HPMC as a health additive will gradually increase. The consumption of HPMC in the food industry expected to grow further.

3. HPMC For Construction

In Construction drymix mortar industry, Hydroxypropyl Methylcellulose is used as a water-retaining agent and retarder for cement mortar to make the mortar pumpable. HPMC Used as a binder in plaster, plaster, putty powder or other building materials to improve spreadability and prolong work time. HPMC can be used as paste tile, marble, plastic decoration, paste reinforcement, and can also reduce the amount of cement. The water-retaining performance of HPMC prevents the slurry from cracking due to drying too quickly after application, and enhances the strength after hardening.

Hydroxypropyl Methylcellulose Benefits

Hydroxypropyl methylcellulose (HPMC) offers a wide range of benefits across different industries. HPMC versatile nature as thickener, stabilizer, film-former, and water-retaining agent makes it an indispensable ingredient in pharmaceuticals, food products, cosmetics, and construction materials. Whether it's providing controlled drug release in pharmaceutical formulations, improving texture and stability in food products, enhancing the performance of cosmetic formulations, or optimizing the properties of construction materials, HPMC plays a vital role.HPMC offers numerous benefits due to its unique properties, making it a valuable ingredient in many products.

• Pharmaceutical Benefits:

a. Controlled Drug Release: HPMC is commonly used as a matrix former in oral solid dosage forms, such as tablets and capsules. It provides controlled drug release, ensuring a steady and sustained release of the active pharmaceutical ingredient (API) over an extended period. This feature is particularly beneficial for drugs that require a slow release pattern to maintain therapeutic efficacy.

b. Film Coating: HPMC forms a uniform and smooth film when applied to tablets or capsules, offering protection against environmental factors such as moisture, light, and air. It also improves the appearance, swallowability, and stability of the dosage form.

c. Mucoadhesive Properties: HPMC can adhere to the mucosal surfaces, enhancing the contact time and improving drug absorption. This property is useful in the development of various oral and ocular drug delivery systems.

• Food Benefits:

a. Thickening and Stabilization: HPMC acts as a thickening and stabilizing agent in food products. It imparts viscosity, texture, and creaminess to sauces, dressings, and dairy products. It prevents phase separation and maintains the homogeneity of food formulations.

b. Fat Replacement: HPMC can be used as a fat replacer in low-fat food products. It mimics the mouthfeel and texture of fats, providing a desirable sensory experience while reducing the calorie content.

c. Water Retention: HPMC has the ability to retain water, thereby preventing moisture loss and maintaining the juiciness and freshness of food products. It is particularly useful in baked goods, where it improves shelf life and texture.

• Cosmetics Benefits:

a. Thickening and Emulsifying Agent: HPMC cellulose is widely used in cosmetic formulations, such as creams, lotions, and shampoos, due to its excellent thickening and emulsifying properties. It improves the stability and consistency of cosmetic products, allowing for better spreadability and ease of application.

b. Film-Forming: When applied to the skin or hair, HPMC cellulose forms a protective film that helps to retain moisture, reducing water loss and maintaining hydration. It also enhances the longevity of cosmetic products on the skin or hair surface.

c. Suspending Agent: HPMC can suspend solid particles in cosmetic formulations, preventing their settling or sedimentation. This property is particularly useful in suspensions, scrubs, and exfoliating products.

• Construction Benefits:

a. Cement and Mortar Additive: HPMC acts as a thickener and water-retaining agent in cement-based products, such as mortars, tile adhesives, and renders. It improves workability, adhesion, and sag resistance, while reducing cracking and shrinkage.

b. Improved Open Time: Open time refers to the duration during which a construction material remains workable after application. HPMC extends the open time of adhesives, allowing for easier positioning and adjustment of tiles, wallpapers, and other materials.

c. Water Resistance: HPMC enhances the water resistance of construction materials, making them more durable and resistant to moisture-related damage. It improves the overall performance and lifespan of buildings and structures.

Overall, the hydroxypropyl methylcellulose benefits are vast and diverse. Its multifunctional properties make it an essential ingredient in a wide range of products, providing improved performance, stability, and user experience. As research and technology continue to advance, HPMC celluloseis likely to find even more applications in various industries, further demonstrating its value and versatility.

O processo de fabricação de hidroxipropil metilcelulose (HPMC) envolve várias etapas para modificar a celulose, um polímero natural derivado de fontes vegetais. O processo inclui tratamento químico e reação para introduzir grupos hidroxipropil e metila na estrutura da celulose. Vamos explorar o processo de fabricação do HPMC em detalhes.

• Extração de celulose:

O processo começa com a extração de celulose de fontes vegetais. Fontes comuns incluem polpa de madeira, algodão ou outros materiais vegetais fibrosos. A celulose é normalmente obtida por meio de uma série de tratamentos mecânicos e químicos, que envolvem a quebra do material vegetal e a remoção de impurezas para obter um material de celulose purificado.

• Tratamento do álcali:

Uma vez que a celulose é extraída, ela passa por um tratamento alcalino para remover os componentes da hemicelulose e da lignina. Este tratamento envolve a imersão de celulose em uma solução alcalina, como hidróxido de sódio (NaOH), para quebrar os materiais não celulósicos. O resultado é celulose purificada com um maior grau de pureza.

• Etherificação:

A próxima etapa é o processo de eterificação, onde os grupos hidroxipropil e metila são introduzidos na estrutura da celulose. Isto é conseguido através de uma série de reações envolvendo a celulose e reagentes apropriados.

A. Ativação alcalina: A celulose purificada é suspensa em uma solução alcalina, normalmente hidróxido de sódio, para ativar a celulose e torná-la mais reativa.

B. Hidroxipropilação: A celulose ativada é então tratada com óxido de propileno (PO) ou um composto semelhante. O grupo hidroxipropil do PO reage com os grupos hidroxila da celulose, levando à fixação de grupos hidroxipropil na estrutura da celulose.

C. Metilação: Após a etapa de hidroxipropilação, a celulose com grupos hidroxipropil ligados sofre metilação. Isso envolve a reação da celulose hidroxipropilada com cloreto de metila ou um agente de metilação semelhante. O grupo metil do agente metilante reage com os grupos hidroxila restantes na celulose, resultando na introdução de grupos metil na espinha dorsal da celulose.

• Neutralização e lavagem:

Após o processo de eterificação, a mistura de reação é neutralizada para interromper novas reações e ajustar o pH. Soluções ácidas ou básicas são adicionadas para neutralizar qualquer excesso de álcali ou ácido presente na mistura. A mistura neutralizada é então lavada cuidadosamente para remover quaisquer reagentes ou subprodutos residuais, garantindo um produto HPMC purificado.

• Secagem e moagem:

A etapa final no processo de fabricação de HPMC envolve a secagem e moagem do produto HPMC obtido. O produto é tipicamente seco usando ar quente ou métodos de secagem a vácuo para remover a umidade e obter um pó seco. O HPMC seco é então moído para atingir o tamanho de partícula desejado e uniformidade, resultando em um pó fino pronto para embalagem e distribuição.

É importante notar que o processo de fabricação específico do HPMC pode variar ligeiramente entre os diferentes fabricantes e seus métodos proprietários. No entanto, os princípios gerais e as etapas envolvidas no processo permanecem consistentes.

Em conclusão, o processo de fabricação de hidroxipropil metilcelulose (HPMC) envolve a extração de celulose de fontes vegetais, seguido de tratamento alcalino, ativação alcalina, hidroxipropilação, metilação, neutralização, lavagem, secagem, e moagem. Este processo resulta na produção de HPMC, um composto versátil com várias aplicações em indústrias como farmacêutica, alimentos, cosméticos e construção.